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DC Field | Value | Language |
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dc.contributor.author | Surinda Kawichai | en_US |
dc.contributor.author | Wipaporn Natalie Songtaweesin | en_US |
dc.contributor.author | Prissana Wongharn | en_US |
dc.contributor.author | Nittaya Phanuphak | en_US |
dc.contributor.author | Tim R. Cressey | en_US |
dc.contributor.author | Juthamanee Moonwong | en_US |
dc.contributor.author | Anuchit Vasinonta | en_US |
dc.contributor.author | Chutima Saisaengjan | en_US |
dc.contributor.author | Tanat Chinbunchorn | en_US |
dc.contributor.author | Thanyawee Puthanakit | en_US |
dc.date.accessioned | 2022-05-27T08:35:41Z | - |
dc.date.available | 2022-05-27T08:35:41Z | - |
dc.date.issued | 2022-04-01 | en_US |
dc.identifier.issn | 22915222 | en_US |
dc.identifier.other | 2-s2.0-85129653929 | en_US |
dc.identifier.other | 10.2196/25561 | en_US |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85129653929&origin=inward | en_US |
dc.identifier.uri | http://cmuir.cmu.ac.th/jspui/handle/6653943832/73109 | - |
dc.description.abstract | Background: Widespread smartphone use provides opportunities for mobile health HIV prevention strategies among at-risk populations. Objective: This study aims to investigate engagement in a theory-based (information-motivation-behavioral skills model) mobile phone app developed to support HIV pre-exposure prophylaxis (PrEP) adherence among Thai young men who have sex with men (YMSM) and young transgender women (YTGW) in Bangkok, Thailand. Methods: A randomized controlled trial was conducted among HIV-negative YMSM and YTGW aged 15-19 years initiating daily oral PrEP. Participants were randomized to receive either youth-friendly PrEP services (YFS) for 6 months, including monthly contact with site staff (clinic visits or telephone follow-up) and staff consultation access, or YFS plus use of a PrEP adherence support app (YFS+APP). The target population focus group discussion findings and the information-motivation-behavioral skills model informed app development. App features were based on the 3Rs-risk assessment of self-HIV acquisition risk, reminders to take PrEP, and rewards as redeemable points. Dried blood spots quantifying of tenofovir diphosphate were collected at months 3 and 6 to assess PrEP adherence. Tenofovir diphosphate ≥350-699 fmol/punch was classified as fair adherence and ≥700 fmol/punch as good adherence. Data analysis on app use paradata and exit interviews were conducted on the YFS+APP arm after 6 months of follow-up. Results: Between March 2018 and June 2019, 200 participants with a median age of 18 (IQR 17-19) years were enrolled. Overall, 74% (148/200) were YMSM; 87% (87/100) of participants who received YFS+APP logged in to the app and performed weekly HIV acquisition risk assessments (log-in and risk assessment [LRA]). The median duration between the first and last log-in was 3.5 (IQR 1.6-5.6) months, with a median frequency of 6 LRAs (IQR 2-10). Moreover, 22% (22/100) of the participants in the YFS+APP arm were frequent users (LRA≥10) during the 6-month follow-up period. YMSM were 9.3 (95% CI 1.2-74.3) times more likely to be frequent app users than YTGW (P = .04). Frequent app users had higher proportions (12%-16%) of PrEP adherence at both months 3 and 6 compared with infrequent users (LRA<10) and the YFS arm, although this did not reach statistical significance. Of the 100 participants in the YFS+APP arm, 23 (23%) were interviewed. The risk assessment function is perceived as the most useful app feature. Further aesthetic adaptations and a more comprehensive rewards system were suggested by the interviewees. Conclusions: Higher rates of PrEP adherence among frequent app users were observed; however, this was not statistically significant. A short app use duration of 3 months suggests that they may be useful in establishing habits in taking daily PrEP, but not long-term adherence. Further studies on the specific mechanisms of mobile phone apps that influence health behaviors are needed. | en_US |
dc.subject | Medicine | en_US |
dc.title | A Mobile Phone App to Support Adherence to Daily HIV Pre-exposure Prophylaxis Engagement Among Young Men Who Have Sex With Men and Transgender Women Aged 15 to 19 Years in Thailand: Pilot Randomized Controlled Trial | en_US |
dc.type | Journal | en_US |
article.title.sourcetitle | JMIR mHealth and uHealth | en_US |
article.volume | 10 | en_US |
article.stream.affiliations | Chulalongkorn University | en_US |
article.stream.affiliations | University of Liverpool | en_US |
article.stream.affiliations | Faculty of Medicine, Chulalongkorn University | en_US |
article.stream.affiliations | Chiang Mai University | en_US |
article.stream.affiliations | Focal Intelligence Co Ltd | en_US |
article.stream.affiliations | Institute of HIV Research and Innovation | en_US |
Appears in Collections: | CMUL: Journal Articles |
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